ABSTRACT
Objective To explore the relationship between iesion location ot the frst onset acute cerebral infarction(ACI),stroke severity and post-stroke depression (PSD).Methods The lesion Iocations of ACI were observed by CT or MRI.100 patients with the first onset ACI were assessed by Hamilton Depression Scale and the National Institutes of Health Stroke Scale two weeks after stroke.Results There was no significant difference in the incidence of PSD among the patients with left,right and bilateral lesions in acute stroke(23.91％,25.00％,33.33％,x2 =0.2512,P ＞0.05 ).The incidence of PSD had significant difference between the anterior-circulation and posterior-circulation infarction(33.96％,14.89％,x2 =4.8307,P ＜ 0.05 ).Stroke severity was positively correlated withthe incidence of PSD( 16.67％,31.37％,36.36％,x2 =3.9188,P ＜ 0.05 ).Conclusion The incidence of PSD was no significant correlation with the stroke site of patients with the first onset ACI,and the patients with anterior circulation infarction and severe neurological deficit have high incidence of PSD.